Absorption Correction Method for Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Combined Tablet Dosage Form

A new, simple, precise, accurate and sensitive UV ‐ Spectrophotometric absorption correction method has been developed for simultaneous determination of Metoprolol Succinate and Olmesartan Medoxomil in combined tablet dosage form. Methanol was used as solvent. Absorbance correction method was based on the property of additivity of absorbances. The two wavelengths on Olmesartan medoxomil curve were found out where it showed same absorbance, which were 233 and 244 nm. At 244 nm, Olmesartan Medoxomil showed some absorbance while Metoprolol Succinate showed zero absorbance. Both the drugs gave absorbance at 233 nm. The method involved solving of an equation based on measurement of absorbance at two wavelengths 233 and 244 nm. The determinations were made at 233 nm for Metoprolol Succinate and Olmesartan Medoxomil and 244 nm for Olmesartan Medoxomil over the concentration range of 5-25 μg/ml for Metoprolol and 4-20 μg/ml for Olmesartan medoxomil with mean recovery of 99.81 ± 0.45 and 99.45 ± 0.406 % for Metoprolol Succinate and Olmesartan Medoxomil, respectively by absorbance correction method. This method was found to be simple, sensitive, accurate, precise, reproducible and economical and can be applicable for the simultaneous determination of METOPROLOL and OLMESARTAN in combined dosage form.